Previous Clinical Research

Studies Involving Patients


Alzheimer's disease

  • First administration to patients
  • Pharmacokinetics and tolerability
  • Short & long-term efficacy and tolerability
  • Pharmocokinetics of once versus twice daily dosing
  • Double blind efficacy studies
  • Open label extension studies
  • Acetylcholinesterase inhibitors
  • Muscarinic agonists
  • Nicotinic agonists
  • 5-HT3 antagonists
  • NMDA receptor modulators
  • Glial cell modulators
  • Amyloid immunisation
  • Monoclonal antibodies
  • Gamma secretase inhibitors

Mild Cognitive Impairment

  • NMDA receptor modulators
  • Acetylcholinesterase inhibitors

Vascular dementia

  • Vasodilators
  • Glutamatergic modulators
  • Acetylcholinesterase inhibitors
  • Glial cell modulators

Parkinson's disease

  • COMT inhibitor
  • Acetylcholinesterase inhibitors


Studies Involving Healthy Subjects

  • Bioavailability (relative & absolute) & bioequivalence

  • Interaction Studies:

  • Pharmacokinetics


The Research Institute for the Care of Older People

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Royal United Hospital

Combe Park

Bath, BA1 3NG

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